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The exact reason for the transformation of normal to cancerous cells, ie specific cause for many cancers is still unknown. Both environmental and genetic factors have been implicated. Common environmental factors include intake of tobacco in the form of smoking and chewing of tobacco and alcohol consumption, radiation (both ionizing and non-ionizing), infections, excessive fat consumption (diet and obesity), viruses, stress, lack of physical activity, asbestos, certain chemicals and environmental pollutants.